The European Commission (EC) is the executive body of the European Union responsible for proposing legislation, implementing decisions, upholding the Union's treaties and day-to-day running of the EU.

The Commission operates as a cabinet government, with 28 members of the Commission (informally known as "commissioners"). There is one member per member state, though members are bound to represent the interests of the EU as a whole rather than their home state. One of the 28 is the Commission President (currently José Manuel Durão Barroso) proposed by the European Council and elected by the European Parliament. The Council then appoints the other 27 members of the Commission in agreement with the nominated President, and then the 28 members as a single body are subject to a vote of approval by the European Parliament. The first Barroso Commission took office in late 2004 and its successor, under the same President, took office in 2010.

The term "Commission" is used either in the narrow sense of the 28-member College of Commissioners (or College) or to also include the administrative body of about 23,000 European civil servants who are split into departments called Directorates-General and Services. The usual procedural languages of the Commission are English, French and German. The Members of the Commission and their "cabinets" (immediate teams) are based in the Berlaymont building of Brussels.